Atf6a kda
WebATF6 is a key transcriptional activator of the unfolded protein response (UPR), which allows mammalian cells to maintain cellular homeostasis when they are subjected to environmental and physiological stresses that target the ER (reviewed in Shen, 2005 & Prywes, 2005). Web75 kDa. ( Note) Product Note This antibody was raised against the C-terminus of human ATF6 alpha, meaning it can only detect the uncleaved form. ... ATF6A Cellular …
Atf6a kda
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WebPage 5 TH-F6A/F7E CIRCUIT DESCRIPTION The first amplifier is divided into four bands: 100 kHz - 50 signal demodulated by the diode detection circuit is output. MHz, 50MHz - … WebATF6a (90 kDa), which, like XBP1, is a basic leucine zipper transcription factor.11 ATF6a is expressed constitutively in an inactive form. ER stress leads to dissociation of ATF6a from BiP resulting in the translocation of ATF6a to the Golgi apparatus. The subsequent proteolytic cleavage of its cytosolic bZIP domain allows for the release of ...
WebATF6 is originally a 90 kDa type II transmembrane glycoprotein that is converted to a 50 kDa soluble nuclear form, retaining its N-terminal domain, including the leucine zipper. … WebFC experiment of HeLa using 24169-1-AP. 1X10^6 HeLa cells were intracellularly stained with 0.4 ug Anti-Human ATF6 (24169-1-AP) and CoraLite®488-Conjugated AffiniPure …
WebDuring the UPR, PERK can phosphorylate eIF2α, the 90-kDa precursor of ATF6 is cleaved into a 50-kDa protein that functions as a transcription factor, and IRE1 splices a 26-bp intron from Xbp1u, resulting in an active Xbp1s. We found that after treatment with rafoxanide, the expression of phosphorylated eIF2α, ... Webunfolded protein response, activated by oasis family transcription factors, promotes astrocyte differentiation
Web226641 Ensembl ENSG00000118217 ENSMUSG00000026663 UniProt P18850 F6VAN0 RefSeq (mRNA) NM_007348 NM_001081304 RefSeq (protein) NP_031374 …
WebApr 12, 2024 · 豆丁网是面向全球的中文社会化阅读分享平台，拥有商业,教育,研究报告,行业资料,学术论文,认证考试,星座,心理学等数亿实用 ... hallowsims storm hairWebMay 1, 2024 · Furthermore, ATF6α inhibition through Ceapin-A7, or Atf6a deletion, disrupted transforming growth factor β (TGFβ)-mediated activation of primary human hepatic stellate cells (hHSCs) or murine hepatic stellate cells (mHSCs), respectively. We investigated the fibrogenic role of ATF6α in vivo through conditional HSC-specific Atf6a deletion. burg pyrmont moselWebAfter 30 min of TG treatment, a V5 reactive band was detected migrating at about 90 kDa (Fig. 3A). When cells were pretreated with ammonium chloride, before treatment with … hallow sims sim file shareWebThe basic domain of ATF6 functions as a nuclear localization signal and the basic leucine-zipper domain is sufficient for association with the NF-Y trimer and binding to ERSE. During the unfolded protein response an approximately 50 kDa fragment containing the cytoplasmic transcription factor domain is released by proteolysis. hallowsims newsea hit the lights hairWebThis form is used to obtain a release from the U.S. Customs and Border Protection (CBP) and notify ATF of actual importation of defense articles imported pursuant to an approved … hallowsims high waisted skirtWebtranscription factors, the most studied of which is ATF6a. When released from GRP78, ATF6a, a single-pass ER trans-membrane protein, translocates to the Golgi where a cleavage event releases a cytoplasmic domain which is a potent but short-lived transcription factor (6). ATF6a, similar to XBP1, burg rabenstein ahorntal bayernWebThe basic domain of ATF6 functions as a nuclear localization signal and the basic leucine-zipper domain is sufficient for association with the NF-Y trimer and binding to ERSE. During the unfolded protein response an approximately 50 kDa fragment containing the cytoplasmic transcription factor domain is released by proteolysis. burgraff ace hardware grand forks nd