Cytosolic phospholipase
WebFeb 1, 2004 · Cytosolic phospholipase A 2 (cPLA 2) comprises a widely expressed family of enzymes, some members of which have the properties required of signal … WebJun 15, 2024 · Background Apolipoprotein E4 (APOE4) is associated with a greater response to neuroinflammation and the risk of developing late-onset Alzheimer’s disease …
Cytosolic phospholipase
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WebAs the initial enzyme in neuroinflammation, cytosolic phospholipase A 2 (cPLA2) can hydrolyze membranous phosphatides at the sn-2 position in a preferential way to release lysophospholipids and ω3-polyunsaturated fatty acid dominated by arachidonic acid, thereby inducing secondary injuries. WebJun 2, 2024 · As the initial enzyme in neuroinflammation, cytosolic phospholipase A2(cPLA2) can hydrolyze membranous phosphatides at the sn-2 position in a preferential way to release lysophospholipids and ω3-polyunsaturated fatty acid dominated by arachidonic acid, thereby inducing secondary injuries.
WebJun 1, 2024 · Phospholipase A 2 (PLA 2) enzymes recognize the sn-2 acyl bond of glycerophospholipids and hydrolyze the bond. The cytosolic PLA 2 (cPLA 2) enzyme is activated by various inflammatory stimuli and preferentially cleaves arachidonic acid (AA) from membrane phospholipid ( Kudo and Murakami, 2002; Ghosh et al., 2006 ). WebDec 12, 2008 · Cytosolic Phospholipase A2-α (cPLA2-α) provides intracellular arachidonic acid to supply both cyclooxygenase and lipoxygenase pathways. We aim to determine …
WebAs the initial enzyme in neuroinflammation, cytosolic phospholipase A 2 (cPLA2) can hydrolyze membranous phosphatides at the sn-2 position in a preferential way to release … WebCytosolic phospholipase A2 is an enzyme that in humans is encoded by the PLA2G4A gene. [5] [6] Function [ edit] This gene encodes a member of the cytosolic …
WebPhospholipase a2 activity. Specific Function. Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. Pfam Domain Function.
WebMar 1, 2014 · Here, we show that cytosolic phospholipase A 2 ε (cPLA 2 ε, also known as PLA2G4E) is targeted to the membrane compartments of the clathrin-independent endocytic route through a C-terminal stretch of positively charged amino acids, which allows the enzyme to interact with phosphoinositide lipids [especially PI (4,5)P 2] that are enriched … portable wooden dance floorsWebAug 1, 2015 · OVERVIEW OF THE MAMMALIAN PHOSPHOLIPASE A 2 FAMILY. The mammalian phospholipase A 2 (PLA 2) family is comprised of six types of diverse enzymes: GIV PLA 2 [cytosolic PLA 2 (cPLA 2)], GVI PLA 2 [calcium-independent PLA 2 (iPLA 2)], GVII and GVIII PLA 2 [platelet-activating factor-acetylhydrolases (PAF-AHs)], … portable wooden outdoor picnic wine tableWebMar 13, 2001 · To clarify the role of AA in tumorigenesis, we have examined the effect of deleting the group IV cytosolic phospholipase A 2 (cPLA 2) locus (Pla2g4). We report that Apc Min/+, cPLA 2−/− mice show an 83% reduction in tumor number in the small intestine compared with littermates with genotypes Apc Min/+, cPLA 2+/− and Apc Min/+, cPLA 2+/+. portable wood burning stove for indoorsWebThe discovery of the cytosolic phospholipase A 2 has added new insight into the cell signaling events that initiate the ‘arachidonate cascade’ described in Chapter 11. The sequence of the cytosolic phospholipase A 2 has been deduced from the cDNA isolated from a number of species [20]. The enzyme, mapped to chromosome 1, is highly … portable work bench ebayWebApr 16, 2024 · Calcium-dependent cytosolic phospholipase A 2 (cPLA2) releases arachidonic acid (AA, 20:4 n-6), which plays important functions in storing energy, as a second messenger in neurotransmission, and as the precursor of eicosanoids [ 4, 5 ]. portable work bench menardsWebThe secretory phospholipase A2IIa (sPLA2IIa) is an important inflammatory enzyme that catalyse the hydrolysis of membrane phospholipids into arachidonic and … portable work light near meWebApr 16, 2024 · Background Apolipoprotein E4 (APOE4) is associated with a greater response to neuroinflammation and the risk of developing late-onset Alzheimer’s disease … portable work bench tool box