WebMar 25, 2024 · The diacylglycerol kinases (DGKs), are a family of membrane lipid kinases in which DGKA plays a pivotal role. 25 Although high levels of DGKA expression in T cells were initially reported, subsequent research revealed that a considerable fraction of cancer cells also exhibited this anomalous pattern. 26, 27 We were interested in the expression ... WebHence, one of the routes used by cancer cells to escape immune response is the metabolization of ceramide ... McCubrey, J.A.; Cocco, L.; et al. Subcellular Localization Relevance and Cancer-Associated Mechanisms of Diacylglycerol Kinases. Int. J. Mol. Sci. 2024, 21, 5297.
Targeting diacylglycerol kinase α impairs lung tumorigenesis by ...
WebMar 1, 2016 · Diacylglycerol kinases as emerging potential drug targets for a variety of diseases. Curr. Drug Targets., 9 (2008), pp. 626-640. ... Diacylglycerol kinase α promotes 3D cancer cell growth and limits drug sensitivity through functional interaction with Src. Oncotarget., 5 (2014), pp. 9710-9726. WebApr 1, 2024 · Diacylglycerol kinases in cancer. Advances in Biological Regulation, Volume 63, 2024, pp. 22-31. Show abstract. Diacylglycerol kinases (DGK) are a family of enzymes that catalyze the transformation of diacylglycerol into phosphatidic acid. In T lymphocytes, DGKα and ζ limit the activation of the PLCγ/Ras/ERK axis, providing a … grapes choking
Downregulation of Diacylglycerol kinase zeta (DGKZ) …
WebDiacylglycerol kinase alpha. DGK alpha is an enzyme that catalyzes the conversion of diacylglycerol to phosphatidic acid, thus regulating the level of these substances in the cell [4]. Diacylglycerol kinase alpha acts as a central switch between signaling pathways activated by secondary messengers such as DAG and phosphatidic acid [4]. WebOct 17, 2016 · Diacylglycerol kinases (DGKs) are a family of enzymes that catalyze the metabolism of diacylglycerol (DAG). Two isoforms of DGK, DGKα, and DGKζ, specifically regulate the pool of DAG that is ... WebOct 13, 2024 · C1 domains, cysteine-rich modules originally identified in protein kinase C (PKC) isozymes, are present in multiple signaling … chipping sparrow sound