Read across approach toxicology

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August undefined, 2024

WebSociety of Toxicology (SOT) WebNov 28, 2024 · Read-across is one of the most frequently used alternative tools for hazard assessment, in particular for complex endpoints such as repeated dose or developmental …

Bibra Read-Across

WebMar 27, 2024 · We developed Generalized Read-Across (GenRA) ( Shah et al., 2016) for automated read-across prediction of a property of a chemical (called the target) as a similarity weighted average of the same property from analogues (also referred to as source analogues) ( Low et al., 2013 ). WebRead-across is one approach frequently used in the risk assessment of substances that lack information on their physical-chemical or toxicological properties, or their environmental … impulsive impact of a submerged body

(PDF) Internationalization of read-across as a validated new …

Web1 day ago · Venous thromboembolism (VTE) comprising deep venous thrombosis and pulmonary embolism is a major cause of morbidity and mortality. Short-term immobility-related conditions are a major risk factor for the development of VTE. Paradoxically, long-term immobilized free-ranging hibernating brown bears and paralyzed spinal cord injury … WebMar 10, 2024 · In read-across, available data on chemical structural analogues are used to predict the toxicity potential of the data-poor chemical. This approach has long been recognized by regulatory agencies and used by industry to evaluate the hazards of chemicals for which there are limited direct data. WebJun 10, 2013 · Considerations before embarking on a read-across approach have been discussed at length elsewhere [16,17,19, 20, 27]. The types of considerations vary to a degree depending on the decision context ... impulsive hyperactive behaviors

Use of analogues and read-across in risk assessment

Chemical Categories and Read across Dec - Europa

Webread-across hypothesis and the information requirement to be read across The RAAF defines two general read-across hypotheses: 1. (Bio)transformation into a common toxicant • Toxicokinetic information may support the approach 2. Different compounds have the same type of effects • Toxicodynamic information may support the approach WebGrouping of substances and read-across is one of the most commonly used alternative approaches for filling data gaps in registrations submitted under REACH. This approach … impulsive idea crossword clueWebSep 26, 2024 · A read-across assessment is using the technique of predicting toxicity data for one compound, named as target compound (TC), by using data for the same endpoint … lithium from ocean water

"WebNov 12, 2024 · The aim of regulatory toxicology is to prevent hazardous substances and products from producing adverse effects on human health and on the environment. 100 In … " - Read across approach toxicology

Read across approach toxicology

Navigating through the minefield of read-across tools: A …

WebJan 1, 2024 · These preliminary biological data-driven read-across studies highlight the road to the new generation of read-across approaches that can be applied in chemical safety … WebJul 8, 2024 · Inspired by the increasingly used read-across approach, we created a new type of QSAR, which is based on similarity of chemicals and not on chemical descriptors. A landscape of the chemical universe using 10 million structures was calculated, when based on Tanimoto indices similar chemicals are close and dissimilar chemicals far from each …

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WebComputational Toxicology. Background & definitions • Read-across describes one of the data gap filling techniques used within analogue and category approaches • “Analogue approach” refers to grouping based on a very limited number of chemicals (e.g. target substance) + source substance) • “Category approach” is used when grouping ... WebComputational Toxicology Generalised Read-Across GenRA, research, implementation and practical application. ToxPi. PRIORITIZATION. Interactive Chemica Sl afety for Sustainability Web Application TOXCAST iCSS v0.5 Tool Tip Description of Assays (Data) or . Prioritization Mode whatever is being hovered over Desc Summary Log 80-05-7 80-05-1 80-05 ...

WebAug 8, 2024 · Read-across has become the essential technique to fill toxicological data gaps. Whilst the term “read-across” has been used since the 1980s, until recently it has … WebJoin us for a Generalized Read Across (GenRA) Virtual Training May 23, 2024 11:00 a.m. – 1:30 p.m. EDT The US Environmental Protection Agency (EPA)'s Generalized Read-Across (GenRA) tool is a freely-available, automated approach to make reproducible read-across predictions of toxicity outcomes. This training will include: A presentation overview of …

WebThe use of toxicity data on a structurally-similar compound to evaluate a substance that has been inadequately tested – the so-called “read-across” approach – is a crucial part of the … WebNov 12, 2024 · Chemical grouping and read-across Chemical grouping and read-across approaches take advantage of structural similarities between substances with known toxicology profiles and new chemical entities to infer the expected toxicological behaviour of the latter. 101 This strategy is commonly used in regulatory toxicology as an …

WebRead-across has generated much attention since it may be used as an alternative approach for addressing the information requirements under regulatory programmes, notably the EU's REACH regulation.

WebJan 1, 2024 · Integrating computational chemistry and toxicology can improve the read-across analog approach to fill data gaps in chemical safety assessment. ... The read-across approach starts with structural ... impulsive in chineseWebJul 12, 2013 · Advancing the science of a read-across framework for evaluation of data-poor chemicals incorporating systematic and new approach methods. Regulatory Toxicology and Pharmacology 2024, 137 , 105293. ... Extending the Generalised Read-Across approach (GenRA): A systematic analysis of the impact of physicochemical property information on … lithium from geothermal brineWebDec 2, 2024 · Integrating computational chemistry and toxicology can improve the read-across analog approach to fill data gaps in chemical safety assessment. In read-across, structure-related parameters are compared between a target chemical with insufficient test data and one or more materials with sufficient data. Recent advances have focused on … lithium from waterWebFeb 6, 2024 · Toxicology and Environmental Research and Consulting, Dow Chemical, Midland, Michigan, USA. Search for more papers by this author. Lennart Weltje, ... In addition, the degree of validation needed to provide sufficient confidence in a given read-across approach has to be decided. Another complicating factor is the difference in validation ... impulsive individuals lithium functionWebproposed read-across case, resulting in an output which is suitable for subsequent regulatory consideration of the read-across case. The approach reflects both a need to … lithium from the oceanWebRead-across describes one of the techniques for filling data gaps in either the analogue or category approaches i.e. not to be confused with the “analogue approach” – “Analogue … lithium from seawater